Currently, virtual cameras are not compatible with most native Apple macOS apps such as Safari and FaceTime due to certain restrictions with macOS security. As a result, third-party applications and plugins may not load.

XVCMAC showing a warning popup that the app may not be supported in Safari Browser

If it's your first time running VCam on your computer, you will be greeted with a popup to help get you started in using XSplit in your streaming/conferencing applications, but with a warning about applications that may not support virtual cameras.
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