Hello my name is Steven Taylor or as some may know me in game as Pwndestrian. I set up my stream for league of legends by using two main features. First I add a Screen Region and highlight the whole screen as I use a program (which I will link at the end) to make the game full screen after the loading screen starts. The second part is optional and only can be done if you have multiple screens. I take whatever program I'm going to use for music (iTunes, WMP, Pandora radio) and I find where the song name and artist is displayed and i highlight that with a screen region. i then scale the size of it down so that if fits comfortably just to the left of the minimap, in the bottom right of the game window, right on top of the buttons that no one ever looks at haha. That is how i set up my stream so it's easy to find what I'm listening to and watch me play at the same time.
The program I talked about earlier that I use to make the game full screen without the stream having flashing issues is called ShiftWindow.
If you would like to watch my stream (if i get Xsplit working again) please feel free to on the site http://www.chippermonkey.net
and click my name (Pwndestrian) in the "Streams" tab.
Thank you for reading this guide and i hope it helped.